THE CEREBROSPINAL-FLUID IN PATIENTS WITH MOYAMOYA DISEASE (SPONTANEOUS OCCLUSION OF THE CIRCLE OF WILLIS) CONTAINS HIGH-LEVEL OF BASIC FIBROBLAST GROWTH-FACTOR

被引：94

作者：

TAKAHASHI, A

SAWAMURA, Y

HOUKIN, K

KAMIYAMA, H

ABE, H

机构：

[1] Department of Neurosurgery, Hokkaido University School of Medicine, Sapporo

来源：

NEUROSCIENCE LETTERS | 1993年 / 160卷 / 02期

关键词：

BASIC FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR; MOYAMOYA DISEASE; CEREBROSPINAL FLUID; ANGIOGENESIS; PATHOGENESIS; ENZYME IMMUNOASSAY;

D O I：

10.1016/0304-3940(93)90416-I

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The level of basic fibroblast growth factor (bFGF) in cerebrospinal fluid (CF) was measured by an EIA in 15 patients with moyamoya disease, in 11 patients with atherosclerotic occlusive disease, and in 8 patients with spinal disc disease. In the moyamoya patients, bFGF was found in 13 out of 15 CF samples with a mean value of 101 pg/ml. However, bFGF was detected in only 4 out of 11 patients with atherosclerotic disease with a mean of 8 pg/ml. In all the patients with disc disease, bFGF was not detected. The elevated level of bFGF may play a crucial role in the pathogenesis of moyamoya disease.

引用

页码：214 / 216

页数：3

共 18 条

[11]

NAKAGAWA Y, 1985, CEREBRAL REVASCULARI, P449

[12]

OGATA J, 1993, ANN REPORT 1992 RES, P131

[13] CEREBRAL-HEMORRHAGE IN MOYAMOYA DISEASE AT AUTOPSY [J].

OKA, K ;

YAMASHITA, M ;

SADOSHIMA, S ;

TANAKA, K .

VIRCHOWS ARCHIV A-PATHOLOGICAL ANATOMY AND HISTOPATHOLOGY, 1981, 392 (03) :247-261

[14] CAPILLARY ENDOTHELIAL-CELLS EXPRESS BASIC FIBROBLAST GROWTH-FACTOR, A MITOGEN THAT PROMOTES THEIR OWN GROWTH [J].

SCHWEIGERER, L ;

NEUFELD, G ;

FRIEDMAN, J ;

ABRAHAM, JA ;

FIDDES, JC ;

GOSPODAROWICZ, D .

NATURE, 1987, 325 (6101) :257-259

[15] MONOCLONAL-ANTIBODIES AGAINST HUMAN BASIC FIBROBLAST GROWTH-FACTOR [J].

SENO, M ;

IWANE, M ;

SASADA, R ;

MORIYA, N ;

KUROKAWA, T ;

IGARASHI, K .

HYBRIDOMA, 1989, 8 (02) :209-221

[16]

SUEISHI K, 1993, ANN REPORT 1992 RES, P131

[17]

SUZUKI J, 1908, MOYAMOYA DISEASE, P1

[18] A SENSITIVE ENZYME-IMMUNOASSAY FOR HUMAN BASIC FIBROBLAST GROWTH-FACTOR [J].

WATANABE, H ;

HORI, A ;

SENO, M ;

KOZAI, Y ;

IGARASHI, K ;

ICHIMORI, Y ;

KONDO, K .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1991, 175 (01) :229-235

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