STABILIZATION AND FACILITATED FORMATION OF A BETA-STRUCTURE POLYPEPTIDE BY A POLY(L-GLUTAMIC ACID)-FUNCTIONALIZED MONOLAYER ON WATER

被引:25
作者
HIGASHI, N [1 ]
SHIMOGUCHI, M [1 ]
NIWA, M [1 ]
机构
[1] DOSHISHA UNIV,FAC ENGN,DEPT APPL CHEM,KAMIKYO KU,KYOTO 602,JAPAN
关键词
D O I
10.1021/la00042a003
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
In this communication, we describe unprecedented conformational changes of poly(L-glutamic acid) (PLGA) assembling at the air-water interface. On the basis of the results from spreading experiments and circular dichroism measurements for the freshly prepared amphiphile, which consists of a PLGA segment (polymerization degree, 40) and two long alkyl chains, it was found that the stable beta-structure of PLGA could be produced specifically by assembling the PLGA segment at the air-water interface and even under an acidic pH, ambient temperature. The conformation of the PLGA segment could be readily controlled by changing the monolayer phase.
引用
收藏
页码:1509 / 1510
页数:2
相关论文
共 17 条
  • [1] SPECIFIC INTERACTIONS OF PROTEINS WITH FUNCTIONAL LIPID MONOLAYERS - WAYS OF SIMULATING BIOMEMBRANE PROCESSES
    AHLERS, M
    MULLER, W
    REICHERT, A
    RINGSDORF, H
    VENZMER, J
    [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 1990, 29 (11) : 1269 - 1285
  • [2] CIRCULAR DICHROISM OF POLYPEPTIDE AND PROTEIN CONFORMATIONS - FILM STUDIES
    FASMAN, GD
    HOVING, H
    TIMASHEFF, SN
    [J]. BIOCHEMISTRY, 1970, 9 (17) : 3316 - +
  • [3] FASMAN GD, 1967, POLY ALPHA AMINO ACI, P499
  • [4] PROCEDURE FOR FACILE SYNTHESIS OF AMINO-ACID N-CARBOXYANHYDRIDES
    FULLER, WD
    VERLANDER, MS
    GOODMAN, M
    [J]. BIOPOLYMERS, 1976, 15 (09) : 1869 - 1871
  • [5] COMPUTED CIRCULAR DICHROISM SPECTRA FOR EVALUATION OF PROTEIN CONFORMATION
    GREENFIE.N
    FASMAN, GD
    [J]. BIOCHEMISTRY, 1969, 8 (10) : 4108 - &
  • [6] CHAIN-LENGTH EFFECTS OF A GUEST POLYMER (PEG) ON THE THERMAL-BEHAVIOR OF INTERPOLYMER-COMPLEXED MONOLAYERS AT THE AIR-WATER-INTERFACE
    HIGASHI, N
    SHIBA, H
    NIWA, M
    [J]. MACROMOLECULES, 1990, 23 (25) : 5297 - 5298
  • [7] CHAIN-LENGTH EFFECTS OF POLY(ETHYLENE GLYCOL) ON A MONOLAYER OF A POLY(METHACRYLIC ACID)-BASED AMPHIPHILE AT THE AIR-WATER-INTERFACE
    HIGASHI, N
    SHIBA, H
    NIWA, M
    [J]. MACROMOLECULES, 1989, 22 (12) : 4650 - 4652
  • [8] ULTRAVIOLET CIRCULAR DICHROISM OF POLYPEPTIDES
    HOLZWARTH, G
    DOTY, P
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1965, 87 (02) : 218 - +
  • [9] IHARA H, 1986, POLYM COMMUN, V27, P282
  • [10] 2 BETA-FORMS OF POLY(L-GLUTAMIC ACID)
    ITOH, K
    FOXMAN, BM
    FASMAN, GD
    [J]. BIOPOLYMERS, 1976, 15 (03) : 419 - 455