STABILIZATION AND FACILITATED FORMATION OF A BETA-STRUCTURE POLYPEPTIDE BY A POLY(L-GLUTAMIC ACID)-FUNCTIONALIZED MONOLAYER ON WATER

被引:25
作者
HIGASHI, N [1 ]
SHIMOGUCHI, M [1 ]
NIWA, M [1 ]
机构
[1] DOSHISHA UNIV,FAC ENGN,DEPT APPL CHEM,KAMIKYO KU,KYOTO 602,JAPAN
关键词
D O I
10.1021/la00042a003
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
In this communication, we describe unprecedented conformational changes of poly(L-glutamic acid) (PLGA) assembling at the air-water interface. On the basis of the results from spreading experiments and circular dichroism measurements for the freshly prepared amphiphile, which consists of a PLGA segment (polymerization degree, 40) and two long alkyl chains, it was found that the stable beta-structure of PLGA could be produced specifically by assembling the PLGA segment at the air-water interface and even under an acidic pH, ambient temperature. The conformation of the PLGA segment could be readily controlled by changing the monolayer phase.
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页码:1509 / 1510
页数:2
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