NEUROKININ-A WITH K+ CHANNEL BLOCKADE POTENTIATES CONTRACTION TO ELECTRICAL-STIMULATION IN HUMAN BRONCHUS

被引:24
作者
BLACK, JL
JOHNSON, PRA
ALOUAN, L
ARMOUR, CL
机构
[1] Department of Pharmacology, University of Sydney, Sydney
关键词
Bronchi (human); Cholinergic neural stimulation; K[!sup]+[!/sup] channels; Neurokinin A;
D O I
10.1016/0014-2999(90)90315-W
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
This study investigated the effects of neurokinin A (NKA) on cholinergic neural responses in human bronchus. NKA (0.1 nM) did not alter the contractile response to submaximal electrical field stimulation. However, K+ channel blockade with 4-aminopyridine (4-AP) (0.1 mM) potentiated the response to electrical field stimulation (to 182 ± 25% of control, n = 4, P < 0.05) and subsequent addition of NKA in the presence of 4-AP produced further potentiation (to 123 ± 6% of the response to 4-AP n = 4, P < 0.05). Neither 4-AP (0.01 or 0.1 mM) nor NKA in the presence of 4-AP potentiated the actions of exogenous acetylcholine but in these experiments 4-AP itself produced a marked direct contractile response. Thus NKA in the presence of K+ channel blockade potentiates cholinergic neural response in human bronchus and this occurs at a prejunctional site. © 1990.
引用
收藏
页码:311 / 317
页数:7
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