AN EFFICIENT SYNTHESIS OF 3-PYRIDYL-N-OXIDE STEROIDS - INHIBITORS OF 5-ALPHA-REDUCTASE

被引:21
作者
HAFFNER, C
机构
[1] Glaxo Inc. Research Institute Five Moore Dr., Research Triangle Park
关键词
D O I
10.1016/S0040-4039(00)76215-0
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Nortestosterone was converted into 3-pyridyl steroid (8) which was then further transformed into pyridine N-oxides (13, 14). These compounds were then assayed against the enzyme Sa-reductase.
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页码:1349 / 1352
页数:4
相关论文
共 17 条
[1]   SELECTIVE RETENTION OF DIHYDROTESTO-STERONE BY PROSTATIC NUCLEI [J].
ANDERSON, KM ;
LIAO, S .
NATURE, 1968, 219 (5151) :277-&
[2]   STRUCTURAL AND BIOCHEMICAL-PROPERTIES OF CLONED AND EXPRESSED HUMAN AND RAT STEROID 5-ALPHA-REDUCTASES [J].
ANDERSSON, S ;
RUSSELL, DW .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (10) :3640-3644
[3]  
ANDERSSON S, 1989, J BIOL CHEM, V264, P16249
[4]   DELETION OF STEROID 5-ALPHA-REDUCTASE 2-GENE IN MALE PSEUDOHERMAPHRODITISM [J].
ANDERSSON, S ;
BERMAN, DM ;
JENKINS, EP ;
RUSSELL, DW .
NATURE, 1991, 354 (6349) :159-161
[5]  
BRUCHOVSKY N, 1968, J BIOL CHEM, V243, P2012
[6]  
Dixon M., 1964, ENZYMES
[7]   INHIBITION OF STEROID 5-ALPHA-REDUCTASE BY 3-NITROSTEROIDS - SYNTHESIS, MECHANISM OF INHIBITION, AND INVIVO ACTIVITY [J].
HOLT, DA ;
LEVY, MA ;
YEN, HK ;
OH, HJ ;
METCALF, BW ;
WIER, PJ .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1991, 1 (01) :27-32
[8]   INHIBITION OF STEROID 5-ALPHA-REDUCTASE BY UNSATURATED 3-CARBOXYSTEROIDS [J].
HOLT, DA ;
LEVY, MA ;
OH, HJ ;
ERB, JM ;
HEASLIP, JI ;
BRANDT, M ;
LANHARGEST, HY ;
METCALF, BW .
JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (03) :943-950
[9]   GENETIC AND PHARMACOLOGICAL EVIDENCE FOR MORE THAN ONE HUMAN STEROID 5-ALPHA-REDUCTASE [J].
JENKINS, EP ;
ANDERSSON, S ;
IMPERATOMCGINLEY, J ;
WILSON, JD ;
RUSSELL, DW .
JOURNAL OF CLINICAL INVESTIGATION, 1992, 89 (01) :293-300
[10]   MECHANISMS OF ACTION OF AMINOGLUTETHIMIDE AS ENDOCRINE THERAPY OF BREAST-CANCER [J].
LONNING, PE ;
KVINNSLAND, S .
DRUGS, 1988, 35 (06) :685-710