EFFECTS OF EXTRACORPOREAL-CIRCULATION ON RENAL-FUNCTION IN CORONARY SURGICAL PATIENTS

We prospectively studied perioperative changes of renal function in 12 previously normal patients (plasma creatinine <1.5 mg/dL) scheduled for elective coronary surgery. Glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) were measured with inulin and I-125-hippuran clearances before induction of anesthesia, before cardiopulmonary bypass (CPB), during hypo- and normothermic CPB, after sternal closure, and 1 h postoperatively. Renal and systemic vascular resistances were calculated. Urinary N-acetyl-beta-D-glucosaminidase (NAG) and plasma and urine electrolytes were measured, and free water, osmolal, and (creatinine clearances, and fractional excretion of sodium and potassium were calculated before and after surgery. I-125-hippuran clearance was lower than normal in all patients before surgery. During hypothermic CPB, ERPF increased significantly (from 261 +/- 107 to 413 +/- 261 mL/min) and returned toward baseline values during normothermia. GFR was normal before and after surgery and decreased nonsignificantly during CPB. Filtration fraction was above normal before surgery and decreased significantly during CPB (038 +/- 0.09 to 0.18 +/- 0.06). Renal vascular resistance (RVR) was high before surgery and further increased after sternotomy (from 18,086 +/- 6849 to 30,070 +/- 24,427 dynes . s . cm(-5)), decreasing during CPB to 13,9647 +/- 14,662 dynes . s . cm(-5). Urine NAG, creatinine, and free water clearances were normal in all patients both pre- and postoperatively. Osmolal clearance and fractional excretion of sodium increased postoperatively from 1.54 +/- 0.06 to 12.47 +/- 11.37 mL/min, and from 0.44 +/- 0.3 to 6.07 +/- 6.27, respectively. We conclude that renal function does not seem to be adversely affected by CPB. Significant functional alterations, such as decreased ERPF and increased RVR, were found before and during surgery, preceding CPB. These periods could contribute to postoperative renal dysfunction.