SOLUBILITY OF PARABENS IN DIOXANE-WATER MIXTURES

被引：26

作者：

PARUTA, AN

机构：

[1] College of Pharmacy, University of Rhode Island, Kingston, Rhode Island

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1969年 / 58卷 / 02期

关键词：

Dielectric constants—dioxane‐water mixtures; Dielectric requirements—parabens solubility; Parabens solubility—dioxane‐water mixtures; UV spectrophotometry—analysis;

D O I：

10.1002/jps.2600580213

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The solubilities of methyl, ethyl, propyl, and butyl parabens have been determined in aqueous solutions of dioxane at 25°. A dielectric requirement of about 8–10 was found for the above materials. Two‐phase systems were found for the ethyl, propyl, and butyl derivatives over a given composition range for the binary mixture. Phase separation occurred over a broad range of composition for the butyl derivative, intermediate range for propyl, and a narrow range for the ethyl derivative. The two phases were found to be invariant with respect to the concentration of the components of the ternary system. It is suggested that a solvate between the paraben and a fixed composition of the binary mixture is produced forming a biphasic system in equilibrium. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company

引用

页码：204 / &

共 4 条

[1] SOLUBILITY OF SEVERAL SOLUTES AS FUNCTION OF DIELECTRIC CONSTANT OF SUGAR SOLUTIONS [J].