BIOSYNTHESIS OF 6BETA-HYDROXYPROGESTERONE AND 6ALPHA-HYDROXYPROGESTERONE IN HUMAN FOETAL LIVER

被引：25

作者：

LISBOA, BP

GUSTAFSSON, JA

机构：

[1] Karolinska Sjukhwt, Hormonlaboratoriet, Stockholm

[2] Kemiska Institutionen, Karolinska Institutet, Stockholm, S-104 01

来源：

EUROPEAN JOURNAL OF BIOCHEMISTRY | 1969年 / 9卷 / 04期

关键词：

D O I：

10.1111/j.1432-1033.1969.tb00637.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

After incubation of progesterone with 105000 Xg microsomes of human foetal liver two C21O3 steroids were isolated by ascending one‐dimensional thin‐layer chromatography. Gas chromato‐graphy‐mass spectrometry analysis showed that the compounds were identical with 6β‐ and 6α‐hydroxyprogesterone. The significance of this finding in relation to earlier reports of 6‐hy‐droxylated C21 steroids in human pregnancy urine is discussed. Copyright © 1969, Wiley Blackwell. All rights reserved

引用

页码：503 / +

页数：1

共 33 条

[1] PRESENCE OF 6-BETA-HYDROXYLASE IN HUMAN PLACENTA
BERLINER, DL
SALHANICK, HA
[J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1956, 16 (07) : 903 - 905
[2] METABOLISM OF PROGESTERONE BY PERFUSED PREVIABLE HUMAN FETUS
BIRD, CE
WIQVIST, N
DICZFALUSY, E
SOLOMON, S
[J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1966, 26 (10) : 1144 - +
[3] BOTTIGER LE, 1967, Z KLIN CHEM KLIN BIO, V5, P176
[4] 6-BETA-HYDROXYCORTISOL - A NEW STEROID IN HUMAN URINE
BURSTEIN, S
DORFMAN, RI
NADEL, EM
[J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1954, 53 (01) : 307 - 308
[5] EXCRETION OF NEUTRAL STEROIDS IN URINE OF NEWBORN INFANTS
CATHRO, DM
FORSYTH, CC
BIRCHALL, K
MITCHELL, FL
[J]. JOURNAL OF ENDOCRINOLOGY, 1963, 27 (01) : 53 - &
[6] ISOLATION AND IDENTIFICATION OF EXTREMELY POLAR UNCONJUGATED STEROIDS IN HUMAN PREGNANCY URINE
DIXON, WR
PENNINGT.GW
[J]. JOURNAL OF ENDOCRINOLOGY, 1966, 34 (03) : 281 - &
[7] EXCRETION OF G-OXYGENATED METABOLITES OF PROGESTERONE AND 5BETA-PREGNANE -3ALPHA,17ALPHA,20ALPHA-TRIOL DURING PREGNANCY
FOTHERBY, K
JAMES, F
KAMYAB, S
[J]. JOURNAL OF ENDOCRINOLOGY, 1965, 33 (01) : 133 - &
[8] 6BETA-HYDROXYCORTISOL AND OTHER POLAR CORTICOSTEROIDS - MEASUREMENT AND SIGNIFICANCE IN HUMAN URINE
FRANTZ, AG
JAILER, JW
KATZ, FH
[J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1961, 21 (10) : 1290 - +
[9] FRANTZ AG, 1960, P SOC EXP BIOL MED, V105, P41
[10] BIOSYNTHESIS OF 6BETA-HYDROXYTESTOSTERONE FROM TESTOSTERONE BY HUMAN FETAL LIVER MICROSOMES
GUSTAFSSON, JA
LISBOA, BP
[J]. STEROIDS, 1968, 11 (04) : 555 - +

← 1 2 3 4 →