ANTIBIOTICS FROM WITHIN - ANTIBACTERIALS FROM HUMAN AND ANIMAL SOURCES

被引:23
作者
ELSBACH, P
机构
[1] P. Elsbach is at the Department of Medicine, New York University School of Medicine, New York
关键词
D O I
10.1016/0167-7799(90)90127-J
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
The isolation of potent antibacterial proteins and peptides from human and animal phagocytes has raised the possibility that these 'antibiotics from within' can be used as therapeutic agents. Problems in delivery to and toxicity towards the host must be faced, but rapid progress in defining the structural determinants of the cytotoxic action of these naturally occurring cytotoxins provides a basis for biotechnological development of new classes of antibiotics. © 1990.
引用
收藏
页码:26 / 30
页数:5
相关论文
共 30 条
  • [11] GENNARO R, 1989, SUBCELLULAR BIOCH BL, V17
  • [12] BIOCHEMICAL AND FUNCTIONAL SIMILARITIES BETWEEN HUMAN EOSINOPHIL-DERIVED NEUROTOXIN AND EOSINOPHIL CATIONIC PROTEIN - HOMOLOGY WITH RIBONUCLEASE
    GLEICH, GJ
    LOEGERING, DA
    BELL, MP
    CHECKEL, JL
    ACKERMAN, SJ
    MCKEAN, DJ
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (10) : 3146 - 3150
  • [13] GRAY PW, 1989, J BIOL CHEM, V264, P9505
  • [14] COMPLETE NUCLEOTIDE AND DEDUCED AMINO-ACID SEQUENCES OF HUMAN AND MURINE PREPROCATHEPSIN-L - AN ABUNDANT TRANSCRIPT INDUCED BY TRANSFORMATION OF FIBROBLASTS
    JOSEPH, LJ
    CHANG, LC
    STAMENKOVICH, D
    SUKHATME, VP
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1988, 81 (05) : 1621 - 1629
  • [15] Klebanoff SJ., 1988, INFLAMMATION BASIC P, P391
  • [16] INTERACTION OF HUMAN DEFENSINS WITH ESCHERICHIA-COLI - MECHANISM OF BACTERICIDAL ACTIVITY
    LEHRER, RI
    BARTON, A
    DAHER, KA
    HARWIG, SSL
    GANZ, T
    SELSTED, ME
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1989, 84 (02) : 553 - 561
  • [17] MANNION BA, 1989, CLIN RES, V37, pA435
  • [18] MANNION BA, 1989, J IMMUNOL, V142, P2807
  • [19] ISOLATION OF A COMPLEMENTARY-DNA CLONE ENCODING A PRECURSOR TO HUMAN EOSINOPHIL MAJOR BASIC-PROTEIN
    MCGROGAN, M
    SIMONSEN, C
    SCOTT, R
    GRIFFITH, J
    ELLIS, N
    KENNEDY, J
    CAMPANELLI, D
    NATHAN, C
    GABAY, J
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1988, 168 (06) : 2295 - 2308
  • [20] MORPHOLOGICAL-STUDIES ON THE KILLING OF SCHISTOSOMULA OF SCHISTOSOMA-MANSONI BY HUMAN EOSINOPHIL AND NEUTROPHIL CATIONIC PROTEINS INVITRO
    MCLAREN, DJ
    MCKEAN, JR
    OLSSON, I
    VENGE, P
    KAY, AB
    [J]. PARASITE IMMUNOLOGY, 1981, 3 (04) : 359 - 373