ACUTE EFFECTS OF TRAMADOL IN METHADONE-MAINTAINED VOLUNTEERS

被引：37

作者：

CAMI, K

LAMAS, X

FARRE, M

机构：

[1] Department of Pharmacology and Toxicology, Institut Municipal D’Investigació Mèdica, Barcelona, 08003

来源：

DRUGS | 1994年 / 47卷

关键词：

D O I：

10.2165/00003495-199400471-00007

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The opioid agonist and antagonist properties of tramadol were assessed in 6 male opioid-dependent volunteers enrolled in a methadone maintenance programme. Subjects participated in 3 experimental sessions in which the effects of intramuscular tramadol 100 and 300mg and placebo were evaluated. Tramadol neither produced morphine-like effects nor precipitated a withdrawal syndrome; its subjective, behavioural and physiological effects were not different from those of placebo. Although the results of this study suggest that tramadol has a low abuse liability in opioid-dependent subjects, higher doses should be tested to confirm these data.

引用

页码：39 / 43

页数：5

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