共 11 条
[11]
VOGL SE, 1980, CANCER TREAT REP, V64, P1005
COMBINATION CHEMOTHERAPY FOR PATIENTS WITH ADVANCED-CARCINOMA OF THE CERVIX - TRIAL OF MITOMYCIN-C, VINCRISTINE, BLEOMYCIN, AND CISPLATIN
被引：25
作者：
GIANNONE, L
BRENNER, DE
JONES, HW
GRECO, FA
BURNETT, LS
机构：
[1] VET ADM MED CTR, DIV HEMATOL, 1310 24TH AVE S, NASHVILLE, TN 37203 USA
[2] VANDERBILT UNIV, DEPT MED, DIV ONCOL, NASHVILLE, TN 37240 USA
[3] VANDERBILT UNIV, DEPT OBSTET & GYNECOL, DIV GYNECOL ONCOL, NASHVILLE, TN 37240 USA
关键词：
D O I：
10.1016/0090-8258(87)90271-X
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Sixteen patients with metastatic or recurrent carcinoma of the cervix were treated with combination chemotherapy consisting of mitomycin-C, vincristine, bleomycin, and cisplatin. Seven of 14 (50%) evaluable patients responded. In 2 patients all measurable disease resolved. Median duration of response was 4.5 months. Toxicity was severe and consisted of myelosuppression, pulmonary fibrosis, nausea, vomiting, stomatitis, asthenia, and fever. Two treatment-related deaths occurred. This combination chemotherapy regimen appears to have a response rate similar to other cisplatin containing regimens. Response durations were short and toxicity was severe.
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页码：178 / 182
页数：5
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