CHOLINERGIC STIMULATION ENHANCES LONG-TERM POTENTIATION IN THE CA1 REGION OF RAT HIPPOCAMPUS

被引：172

作者：

BLITZER, RD

GIL, O

LANDAU, EM

机构：

[1] MT SINAI MED CTR,DEPT PHARMACOL,NEW YORK,NY 10029

[2] VET ADM MED CTR,PSYCHIAT SERV,BRONX,NY 10468

来源：

NEUROSCIENCE LETTERS | 1990年 / 119卷 / 02期

关键词：

Acetylcholine; Carbachol; Hippocampus; Long-term potentiation; Rat; Synaptic plasticity;

D O I：

10.1016/0304-3940(90)90835-W

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of the cholinergic agonist carbachol on a putative substrate for memory (long-term potentiation; LTP) was investigated in slices of rat hippocampus (CA1 region). Carbachol (5 μM) increased LTP when the presynaptic depression of the EPSP was controlled. The results indicate that carbachol enhances the effectiveness of the tetanus, probably through postsynaptic mechanisms. This effect may have implications for the role of acetylcholine in memory and the use of cholinergics in memory disorders. © 1990.

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页码：207 / 210

页数：4

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