STUDIES ON SLEEP WAKE EFFECTS OF SEROTONIN REUPTAKE INHIBITORS AND RECEPTOR SUBTYPE INVOLVEMENT

被引：10

作者：

URSIN, R ^{[1
]}

BJORVATN, B ^{[1
]}

SOMMERFELT, L ^{[1
]}

NECKELMANN, D ^{[1
]}

BJORKUM, AA ^{[1
]}

机构：

[1] UNIV BERGEN, DEPT PHYSIOL, N-5014 BERGEN, NORWAY

来源：

JOURNAL OF SLEEP RESEARCH | 1992年 / 1卷 / 03期

关键词：

5-HT MECHANISMS; ALAPROCLATE; RITANSERIN; SLOW-WAVE SLEEP; ZIMELDINE;

D O I：

10.1111/j.1365-2869.1992.tb00031.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Studies with the serotonin uptake inhibitors zimeldine and alaproclate show biphasic effects on the sleep/wake axis in rats and cats. Zimeldine induced an initial waking response succeeded by a small SWS-2 increase in rats. The waking increase was not blocked by the 5-HT2 antagonist ritanserin nor by the putative 5-HT1A antagonist (-)-alprenolol. In cats, zimeldine induced initial behavioural changes which were succeeded by a large SWS-2 increase. Alaproclate gave similar initial responses as zimeldine in both species, and was succeeded by a moderate sleep increase in cats but not in rats. The complex sleep/wake effects following the serotonin uptake inhibitors may result from simultaneous induction of incompatible serotonergic effects.

引用

页码：157 / 162

页数：6