A HIGH-RESOLUTION MEIOTIC MAPPING PANEL FOR THE PERICENTROMERIC REGION OF CHROMOSOME-10

被引：13

作者：

LICHTER, JB

WU, JS

MILLER, D

GOODFELLOW, PJ

KIDD, KK

机构：

[1] YALE UNIV,SCH MED,DEPT GENET,I-311 SHM,333 CEDAR ST,NEW HAVEN,CT 06510

[2] UNIV CALIF LOS ANGELES,LOS ANGELES CTY HARBOR MED CTR,TORRANCE,CA 90509

[3] UNIV BRITISH COLUMBIA,DEPT MED GENET,VANCOUVER V6T 1Z3,BC,CANADA

来源：

GENOMICS | 1992年 / 13卷 / 03期

关键词：

D O I：

10.1016/0888-7543(92)90131-B

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Familial multiple endocrine neoplasia type 2A (MEN 2A) is a dominantly inherited cancer syndrome characterized by tumors in tissues derived from the neural crest. The disease manifests as medullary carcinoma of the thyroid, pheochromocytoma, and hyperparathyroidism. The MEN2A locus has been mapped near the centromere of chromosome 10 by linkage analysis. Statistical analyses have not resolved the location of MEN2A among several close markers. We have used our family material to refine the positions of 36 identified and confirmed crossovers among the markers most closely linked to MEN2A. This high-resolution meiotic mapping panel will help order loci in this pericentromeric region and narrow the region in which MEN2A maps. © 1992.

引用

页码：607 / 612

页数：6

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