LACTATE METABOLISM IN NORMAL AND GROWTH-RETARDED HUMAN FETUSES

Lactate concentration and oxygen content were measured in 21 normal (AGA) and 34 intrauterine growth-retarded (IUGR) infants at the time of elective cesarean section. Maternal lactate and umbilical arterial and venous lactate concentrations were significantly higher in IUGR infants compared with AGA infants. However, when IUGR patients were subdivided according to pulsa-tility index (PI) measurements of the umbilical artery, no differences were detected between AGA and IUGR patients with PI <4 SD, whereas IUGR patients with PI >4 SD had higher lactate concentrations in maternal arterial blood and umbilical arterial and venous blood from both other groups. There was a significant inverse linear relationship between umbilical arterial lactate concentration and umbilical venoarterial differences for both lactate concentrations and for lactate/oxygen quotients. These relationships were significantly different in IUGR fetuses with PI >4 SD compared with AGA and IUGR fetuses with PI <4 SD. AGA and IUGR fetuses with PI <4 SD have arterial lactate concentrations <2 mM even at low oxygen concentrations (O2 content <2 mM, O2 saturations <20%). At comparable levels of oxygenation, IUGR fetuses with PI >4 SD have a marked lactacidemia. The data suggest that coupling Doppler assessment of flow velocimetry with biochemical analyses of fetal blood can be useful in identifying a subset of IUGR human fetuses at risk of intrauterine hypoxia. © 1990 International Pediatric Research Foundation, Inc.