DOPAMINE D2 RECEPTOR ANTAGONISTS INDUCE IMMEDIATE EARLY GENES IN THE RAT STRIATUM

被引：51

作者：

ROGUE, P

VINCENDON, G

机构：

[1] Laboratoire de Neurobiologie Moléculaire des Interactions Cellulaires, (UPR 416 du CNRS), Centre de Neurochimie, 67084 Strasbourg

来源：

BRAIN RESEARCH BULLETIN | 1992年 / 29卷 / 3-4期

关键词：

DOPAMINE D2 RECEPTORS; NEUROLEPTIC DRUGS; C-JUN; ZIF-268; C-FOS; STRIATUM;

D O I：

10.1016/0361-9230(92)90084-B

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The acute effects of dopamine D2 antagonists and agonists on the expression of c-jun, zif-268, ETR101 and c-fos in the rat striatum were studied. A single injection IP of haloperidol (2 mg/kg) or sulpiride (100 mg/kg) produced a rapid and transient increase in c-jun, zif-268 and c-fos mRNA. ETR101 was not activated. These inductions were dose dependent and were specifically blocked by pretreatment with a D2 agonist (1 mg/kg quinelorane). Quinelorane alone had no effect. Thus, dopamine D2 receptors inhibit the expression of a particular set of immediate early genes in the striatum.

引用

页码：469 / 472

页数：4

共 16 条

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