AMINO ACID TRANSPORT IN ADULT DIAPHYSEAL BONE CONTRAST WITH AMINO ACID TRANSPORT MECHANISMS IN FETAL MEMBRANOUS BONE

1. 1. This report describes a system for in vitro study of amino acid transport in intact sections of adult rat diaphyseal bone. 2. 2. Kinetic analysis of amino acid transport indicates a common transport mechanism for neutral amino and imino acids in adult diaphyseal bone. This is in contrast to evidence for separate transport mechanisms for neutral amino and imino acids in fetal rat calvaria. 3. 3. Removal of Na+ from the incubation medium decreases but does not abolish transport of both neutral amino and imino acids in adult rat diaphysis. 4. 4. The implications of differences in transport mechanisms between fetal membranous and adult diaphyseal bone are discussed. © 1969.