INFLUENCE OF OVARIECTOMY, ESTROGEN, AND PROGESTERONE ON CATECHOLAMIN CONTENT OF HYPOTHALAMIC NERVE CELLS IN RAT

被引:18
作者
LICHTENSTEIGER, W
KORPELA, K
LANGEMANN, H
KELLER, PJ
机构
[1] Department of Pharmacology University of Zurich, Zurich
[2] (P.J.K.) Hormone Laboratory, the Department of Gynecology and Obstetrics, University of Zurich, Zurich
关键词
D O I
10.1016/0006-8993(69)90094-8
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
In female rats the intensity of the catecholamine fluorescence was measured in nerve cell bodies of tubero-infundibular neurons by microfluorimetry, and the serum LH and FSH levels were determined. Ovariectomy interrupted the typical sequence in the frequency distributions of relative fluorescence intensity of the normal estrous cycle. A frequency distribution comparable to the type of diestrous day 2 was observed between 3 and 7 weeks after ovariectomy together with an LH level similar to diestrous day 2 but an FSH level higher than during the cycle. Ten μg of estradiol dipropionate caused a shift of the frequency distribution which then resembled the type of diestrous day 1, and a fall of LH and FSH levels. Very high doses were less effective in both respects. Effects of progesterone depended on whether it was administered with or without estrogen. The findings further support the hypothesis of a functional relationship between different states of activity of these tubero-infundibular neurons and the control of gonadotropin secretion. © 1969.
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页码:199 / +
页数:1
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