EFFECTS OF THE TETRONIC ACID-DERIVATIVES AO33 (LOSIGAMONE) AND AO78 ON EPILEPTIFORM ACTIVITY AND ON STIMULUS-INDUCED CALCIUM-CONCENTRATION CHANGES IN RAT HIPPOCAMPAL SLICES

被引：24

作者：

KOHR, G ^{[1
]}

HEINEMANN, U ^{[1
]}

机构：

[1] UNIV COLOGNE,ZENTRUM PHYSIOL & PATHOPHYSIOL,INST NEUROPHYSIOL,W-5000 COLOGNE 41,GERMANY

来源：

EPILEPSY RESEARCH | 1990年 / 7卷 / 01期

关键词：

(Rat); Anticonvulsant; Hippocampus; Losigamone; Low calcium; Low magnesium; Picrotoxin; Tetronic acid derivatives;

D O I：

10.1016/0920-1211(90)90053-X

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The effects of members of a new class anticonvulsants, the tetronic acid derivatives, were studied in 3 in vitro models of epileptogenesis in rat hippocampal slices; the picrotoxin, the low magnesium and the low calcium model. The effects of AO33 (losigamone) and AO78 on stimulus-induced decreases in extracellular calcium concentration were also investigated. In all 3 models of epileptogenesis, both drugs blocked spontaneous and reduced stimulus-induced epileptiform discharges dose dependently and reversibly. Stimulus-induced changes in [Ca2+]0 were markedly diminished by these agents. The fact that the tetronic acid derivatives block the low Ca seizure-like events which develop independently from chemical synaptic transmission suggests that these agents have non-synaptic or direct membrane actions with subsequently reduced cellular excitability. © 1990.

引用

页码：49 / 58

页数：10

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