IRREVERSIBLE ENZYME INHIBITORS .176. ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITORS OF DIHYDROFOLATE REDUCTASE DERIVED FROM 4,6-DIAMINO-1,2-DIHYDRO-2,2-DIMETHYL-1-PHENYL-S-TRIAZINE BY ETHER BRIDGING TO A TERMINAL SULFONYL FLUORIDE

被引：5

作者：

BAKER, BR

ASHTON, WT

机构：

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1970年 / 13卷 / 06期

关键词：

D O I：

10.1021/jm00300a029

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

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页码：1149 / &

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[3] IRREVERSIBLE ENZYME INHIBITORS .166. ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITORS OF DIHYDROFOLIC REDUCTASE DERIVED FROM 2,4-DIAMINO-5-(3,4-DICHLOROPHENYL)PYRIMIDINE WITH 6 SUBSTITUENTS AND SOME FACTORS IN THEIR CELL WALL TRANSPORT [J].

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[4] IRREVERSIBLE ENZYME INHIBITORS .154. SOME FACTORS IN CELL WALL TRANSPORT OF ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITORS OF DIHYDROFOLIC REDUCTASE DERIVED FROM 5-SUBSTITUTED 2,4-DIAMINOPYRIMIDINES [J].

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[5] IRREVERSIBLE ENZYME INHIBITORS . 140 . ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITORS DERIVED FROM 1-(3-CHLOROPHENYL)-4,6-DIAMINO-1,2-DIHYDRO-2,2-DIMETHYL-S-TRIAZINE [J].

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[6] IRREVERSIBLE ENZYME INHIBITORS . 133 . STUDIES ON DIFFERENTIAL IRREVERSIBLE INHIBITION OF DIHYDROFOLIC REDUCTASE FROM 3 STRAINS OF L1210 LEUKEMIA LIVER SPLEEN AND INTESTINE OF MOUSE [J].

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[7] IRREVERSIBLE ENZYME INHIBITORS .173. CURE OF WALKER-256 ASCITES BY RVERSIBLE AND IRREVERSIBLE INHIBITORS OF DIHYDROFOLIC REDUCTASE DERIVED FROM 1-(SUBSTITUTED-PHENYL)-4,6-DIAMINO-1,2-DIHYDRO-2,2-DIMETHYL-S-TRIAZINE [J].

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