POTENCY ASSESSMENT OF FOOT-AND-MOUTH-DISEASE VACCINES IN CATTLE BY MEANS OF ANTIBODY-ASSAYS

被引：8

作者：

AMADORI, M ^{[1
]}

ARCHETTI, IL ^{[1
]}

TOLLIS, M ^{[1
]}

BUONAVOGLIA, C ^{[1
]}

PANINA, GF ^{[1
]}

机构：

[1] IST SUPER SANITA LAB MED VET,ROME,ITALY

来源：

BIOLOGICALS | 1991年 / 19卷 / 03期

关键词：

D O I：

10.1016/1045-1056(91)90034-H

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A tendency has emerged for some years to replace the challenge infection of cattle for the assessment of foot-and-mouth disease (FMD) vaccine potency. This can be actually evaluated by means of antibody assays on cattle sera, at about 3 4 weeks after the vaccination. Serological results can be worked out as single titres (to be compared with a pre-determined threshold level) or as mean antibody titres induced by different vaccine dilutions. However, the assessment of FMDV-specific antibody titres would not fully depict the extent and the efficacy of the immune response of cattle; moreover, the antibody response would not be proportional if potent vaccines are used (≥ 10-12 PD50). Thus, a particular approach is suggested for the serological procedures, which enable credible estimates of potent FMD vaccines to be formulated. © 1991.

引用

页码：191 / 196

页数：6