NOVEL INDOLACTAM-BASED INHIBITORS OF MATRIX METALLOPROTEINASES

被引：49

作者：

CASTELHANO, AL

BILLEDEAU, R

DEWDNEY, N

DONNELLY, S

HORNE, S

KURZ, LJ

LIAK, TJ

MARTIN, R

UPPINGTON, R

YUAN, ZY

KRANTZ, A

机构：

[1] Syntex Discovery Research, Palo Alto, CA 94303

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 13期

关键词：

D O I：

10.1016/0960-894X(95)00233-J

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Potent collagenase inhibitors incorporating a novel indolactam macrocycle, which are accessible by the intramolecular alkylation of N-t-Boc-L-Trp-NH(CH2)(6)OTs under phase transfer conditions, show enhanced activity compared to their acyclic analogs.

引用

页码：1415 / 1420

页数：6

共 34 条

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