LASP-1 (MLN-50) DEFINES A NEW LIM PROTEIN SUBFAMILY CHARACTERIZED BY THE ASSOCIATION OF LIM AND SH3 DOMAINS

被引：148

作者：

TOMASETTO, C ^{[1
]}

MOOGLUTZ, C ^{[1
]}

REGNIER, CH ^{[1
]}

SCHREIBER, V ^{[1
]}

BASSET, P ^{[1
]}

RIO, MC ^{[1
]}

机构：

[1] ULP, INST GENET & BIOL MOLEC & CELLULAIRE,INSERM,CNRS, U184, F-67404 ILLKIRCH GRAFFENSTADEN, FRANCE

来源：

FEBS LETTERS | 1995年 / 373卷 / 03期

关键词：

LASP-1; LIM; SH3; BREAST CANCER; C-ERBB-2;

D O I：

10.1016/0014-5793(95)01040-L

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

MLN 50 was previously identified in a cDNA library of breast cancer metastasis. In this study, we show that MLN 50, which is expressed at a basal level in normal tissues, is overexpressed in 8% of human breast carcinomas most often together with c-erbB-2, MLN 50 cDNA encodes a putative protein of 261 residues, named Lasp-1 (LIM and SH3 protein) since it contains a LIM motif and a domain of Src homology region 3 (SH3) at the amino- and the C-terminal parts of the protein, respectively. Thus, Lasp-1 defines a new LIM protein subfamily.

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页码：245 / 249

页数：5

相关论文

共 39 条

[1] PROLINE-RICH SEQUENCES THAT BIND TO SRC HOMOLOGY-3 DOMAINS WITH INDIVIDUAL SPECIFICITIES [J].

ALEXANDROPOULOS, K ;

CHENG, GH ;

BALTIMORE, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (08) :3110-3114

[2] BASIC LOCAL ALIGNMENT SEARCH TOOL [J].

ALTSCHUL, SF ;

GISH, W ;

MILLER, W ;

MYERS, EW ;

LIPMAN, DJ .

JOURNAL OF MOLECULAR BIOLOGY, 1990, 215 (03) :403-410

[3] A LIM MOTIF IS PRESENT IN A POLLEN-SPECIFIC PROTEIN [J].

BALTZ, R ;

EVRARD, JL ;

DOMON, C ;

STEINMETZ, A .

PLANT CELL, 1992, 4 (12) :1465-1466

[4] SH3 DOMAINS DIRECT CELLULAR-LOCALIZATION OF SIGNALING MOLECULES [J].

BARSAGI, D ;

ROTIN, D ;

BATZER, A ;

MANDIYAN, V ;

SCHLESSINGER, J .

CELL, 1993, 74 (01) :83-91

[5] ISOLATION OF BIOLOGICALLY-ACTIVE RIBONUCLEIC-ACID FROM SOURCES ENRICHED IN RIBONUCLEASE [J].

CHIRGWIN, JM ;

PRZYBYLA, AE ;

MACDONALD, RJ ;

RUTTER, WJ .

BIOCHEMISTRY, 1979, 18 (24) :5294-5299

[6] AN INTERACTION BETWEEN ZYXIN AND ALPHA-ACTININ [J].

CRAWFORD, AW ;

MICHELSEN, JW ;

BECKERLE, MC .

JOURNAL OF CELL BIOLOGY, 1992, 116 (06) :1381-1393

[7] BIOCHEMICAL AND MOLECULAR CHARACTERIZATION OF THE CHICKEN CYSTEINE-RICH PROTEIN, A DEVELOPMENTALLY-REGULATED LIM-DOMAIN PROTEIN THAT IS ASSOCIATED WITH THE ACTIN CYTOSKELETON [J].

CRAWFORD, AW ;

PINO, JD ;

BECKERLE, MC .

JOURNAL OF CELL BIOLOGY, 1994, 124 (1-2) :117-127

[8]

FEINBERG AP, 1983, ANAL BIOCHEM, V112, P195

[9] PROGRESSIVE SEQUENCE ALIGNMENT AS A PREREQUISITE TO CORRECT PHYLOGENETIC TREES [J].

FENG, DF ;

DOOLITTLE, RF .

JOURNAL OF MOLECULAR EVOLUTION, 1987, 25 (04) :351-360

[10] LOCALIZATION OF A NOVEL V-ERBB-RELATED GENE, C-ERBB-2, ON HUMAN CHROMOSOME-17 AND ITS AMPLIFICATION IN A GASTRIC-CANCER CELL-LINE [J].

FUKUSHIGE, S ;

MATSUBARA, K ;

YOSHIDA, M ;

SASAKI, M ;

SUZUKI, T ;

SEMBA, K ;

TOYOSHIMA, K ;

YAMAMOTO, T .

MOLECULAR AND CELLULAR BIOLOGY, 1986, 6 (03) :955-958

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