INHIBITION OF ADJUVANT DISEASE IN RATS BY INTERFERON-INDUCING AGENT PYRAN COPOLYMER

被引：38

作者：

KAPUSTA, MA

MENDELSON, J

机构：

[1] Rheumatology Research, Department of Medicine, Jewish General Hospital, Institute of Medical Research, Montreal, Quebec

[2] Division of Infectious Diseases and Microbiology, Department of Medicine, Jewish General Hospital, Lady Davis Institute of Medical Research, Montreal

来源：

ARTHRITIS AND RHEUMATISM | 1969年 / 12卷 / 05期

关键词：

D O I：

10.1002/art.1780120502

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The effect of pyran copolymer, a synthetic polyanionic interferon inducer, was studied in adjuvant‐induced disease in rats. This agent was shown to induce interferon in Sprague‐Dawley and CD®F rats and to inhibit adjuvant‐induced arthritis in both species of rats. Splenomegaly was inhibited in CD®F rats. Based on the time at which single injections were most effective, pyran did not seem to have an antiinflammatory effect and its action was different from antilymphocyte serum. These data open the question of the role of a virus or virus‐like microorganism in the pathogenesis of adjuvant disease. A hypothesis reconciling immune participation in this disease with the role of a possible infectious agent is presented. Copyright © 1969 American College of Rheumatology

引用

页码：463 / +

页数：1

共 36 条

[31] INTERFERON - PROTECTION OF CELLS INFECTED WITH AN INTRACELLULAR PROTOZOAN (TOXOPLASMA GONDII) [J].

REMINGTON, JS ;

MERIGAN, TC .

SCIENCE, 1968, 161 (3843) :804-+

[32]

SANDFORD KK, 1948, JNCI-J NATL CANCER I, V9, P229

[33]

SNEDECOR GW, 1956, STATISTICAL METHODS

[34] INTERFERON - A REVIEW AND ANALYSIS OF RECENT OBSERVATIONS [J].

WAGNER, RR .

AMERICAN JOURNAL OF MEDICINE, 1965, 38 (05) :726-+

[35] PASSIVE TRANSFER OF ADJUVANT ARTHRITIS IN RATSWITH LIVING LYMPHOID CELLS OF SENSITIZED DONORS [J].

WAKSMAN, BH ;

WENNERSTROM, C .

INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY, 1963, 23 (3-4) :129-&

[36] INTERFERON - NONVIRAL INFECTIONS AND NONVIRAL INDUCERS [J].

WEINSTEIN, L ;

CHANG, TW .

ANNALS OF INTERNAL MEDICINE, 1968, 69 (06) :1315-+

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