GABA(B) RECEPTORS

被引:215
作者
KERR, DIB
ONG, J
机构
[1] Department of Anaesthesia and Intensive Care, The University of Adelaide, Adelaide
关键词
GABA; GABA(B) RECEPTORS; GABA(B) AGONISTS AND ANTAGONISTS; STRUCTURE ACTION RELATIONSHIPS; CLINICAL IMPLICATIONS; FUNCTIONAL RESPONSES;
D O I
10.1016/0163-7258(95)00016-A
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
GABA(B) receptors are a distinct subclass of receptors for the major inhibitory transmitter 4-aminobutanoic acid (GABA) that mediate depression of synaptic transmission and contribute to the inhibition controlling neuronal excitability. The development of specific agonists and antagonists for these receptors has led to a better understanding of their physiology and pharmacology, highlighting their diverse coupling to different intracellular effecters through G(i)/G(o) proteins. This review emphasises our current knowledge of the neurophysiology and neurochemistry of GABA(B) receptors, including their heterogeneity, as well as the therapeutic potential of drugs acting at these sites.
引用
收藏
页码:187 / 246
页数:60
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