WHAT ROLES HAVE ANTIINTERFERON ANTIBODIES IN PHYSIOLOGY AND PATHOLOGY

被引：6

作者：

BOCCI, V

机构：

[1] Istituto di Fisiologia Generate e Scienza dell'Alimentazione, Università degli Siudi di Siena, Siena, 53100

来源：

RESEARCH IN CLINIC AND LABORATORY | 1991年 / 21卷 / 01期

关键词：

ANTIBODIES; INTERFERONS; INTERLEUKINS;

D O I：

10.1007/BF02919115

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Until recently the generation of antibodies to interferons (IFNs) was considered an unlikely event, while it is now clear that natural interferons (except IFN-beta) are practically nonimmunogenic, although recombinant interferons give rise to antibodies in about 30% of patients with occasional clinical complications. By realizing that normal individuals display spontaneously traces of IFN autoantibodies, in this review it is suggested that (if immunotherapy has to succeed) new generations of recombinant proteins should be the least antigenic as possible.

引用

页码：79 / 84

页数：6