INVITRO METHOD SIMULATING DRUG RELEASE FROM VISCOUS EYE DROPS IN RABBIT AND MAN

被引：11

作者：

MELISDECERF, C ^{[1
]}

VANOOTEGHEM, M ^{[1
]}

机构：

[1] UNIV ANTWERP,GALENICAL PHARM,DEPT PHARMACEUT SCI,B-2610 WILRIJK,BELGIUM

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1979年 / 31卷 / 01期

关键词：

D O I：

10.1111/j.2042-7158.1979.tb13412.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A method has been developed using a diffusion cell in an attempt to determine the drug release from viscous solutions under conditions simulating the blinking movements in the rabbit and human eye. Diffusion coefficients were determined at rest and at different velocities. For the solutions at rest, corresponding with the conditions at the surface of the rabbit cornea, the diffusion velocity decreases with increasing viscosity. When the solution is moved at a velocity corresponding to that of lachrymal fluid at the surface of the human eye, the influence of viscosity may be neglected. 1979 Royal Pharmaceutical Society of Great Britain

引用

页码：12 / 15

页数：4