DIASTEREOSELECTIVE ACETYLIDE ADDITIONS TO A [3.2.1]-DIOXABICYCLOOCTANONE - INSTALLATION OF THE C(4) STEREOCENTER OF (+)-ZARAGOZIC-ACID-C

被引：11

作者：

CARREIRA, EM

DUBOIS, J

机构：

[1] Contribution # 9012 Amold and Mabel Beckman Laboratory for Chemical Synthesis Division of Chemistry, Chemical Engineering California Institute of Technology Pasadena

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 08期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/0040-4039(95)00035-B

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Nucleophilic addition of lithium acetylides to ketone 2 provides a key intermediate in the synthesis of (+)- zaragozic acid C. The effect of co-solvents (tertiary amines) and additives (LiBr) on the diastereoselection of this reaction has been investigated.

引用

页码：1209 / 1212

页数：4

共 13 条

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