A NOVEL SYNTHESIS OF 19-NOR 1-ALPHA,25-DIHYDROXYVITAMIN D-3 AND RELATED ANALOGS

被引：36

作者：

HUANG, PQ ^{[1
]}

SABBE, K ^{[1
]}

POTTIE, M ^{[1
]}

VANDEWALLE, M ^{[1
]}

机构：

[1] STATE UNIV GHENT,DEPT ORGAN CHEM,SYNTH ORGAN LAB,B-9000 GHENT,BELGIUM

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 45期

关键词：

D O I：

10.1016/0040-4039(95)01730-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

19-Nor-1 alpha,25-dihhyroxyvitamin D-3 (2) was synthesized from A-ring precursor 5 and ketone 4. Two synthesis of 5 were studied; one starting from (-)-quinic acid as a template and one starting from cis-1,3,5-cyclohexanetriol via a chemoenzymatic approach.

引用

页码：8299 / 8302

页数：4

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