REQUIREMENT OF A STABLE SECONDARY STRUCTURE FOR ANTIVIRAL ACTIVITY OF POLYNUCLEOTIDES

被引：112

作者：

DECLERCQ, E

MERIGAN, TC

机构：

[1] Division of Infectious Diseases, Department of Medicine, Stanford University School of Medicine, Stanford, CA

来源：

NATURE | 1969年 / 222卷 / 5199期

关键词：

D O I：

10.1038/2221148a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Several polyribonucleotides, both as single species and when annealed in pairs, are able to induce interferon production in mammalian cells and cellular resistance to virus infection. These studies suggest that a stable secondary, presumably multistranded structure is required for this activity. © 1969 Nature Publishing Group.

引用

页码：1148 / &

共 60 条

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