OCULAR HYPOTENSIVE ACTIONS OF SEROTONIN ANTAGONIST KETANSERIN ANALOGS

被引：17

作者：

CHIOU, GCY

LI, BHP

机构：

[1] Institute of Ocular Pharmacology, Department of Medical Pharmacology and Toxicology, Texas A&M University College of Medicine, College Station, Texas

来源：

JOURNAL OF OCULAR PHARMACOLOGY | 1992年 / 8卷 / 01期

关键词：

D O I：

10.1089/jop.1992.8.11

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

A series of ketanserin analogs were studied for their effects on intraocular pressure (IOP) recovery curve of rabbits infused with hypertonic saline. Eight out of 31 compounds tested showed a marked delay in IOP recovery indicating that they are potential antiglaucoma agents. Five out of eight compounds showed equal suppression of the IOP recovery curves of treated and contralateral eyes indicating that these compounds could be absorbed systemically to affect the IOP of the contralateral eye. There were three compounds (GC 679, GC 646, and GC 526) which showed more suppression of the IOP recovery curve of the treated eye than that of the contralateral eye, indicating that these drugs might act primarily at the local site to lower the IOP. Therefore, these three compounds could produce antiglaucoma actions with little systemic side effects, if any.

引用

页码：11 / 21

页数：11

共 38 条

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