A PANEL OF DELETED MOUSE X-CHROMOSOME SOMATIC-CELL HYBRIDS DERIVED FROM THE EMBRYONIC STEM CELL LINE HD3 SHOWS PREFERENTIAL BREAKAGE IN THE HPRT-DXHX254E REGION

被引：3

作者：

ARNAUD, D

MATTEI, MG

AVNER, P

机构：

[1] INST PASTEUR,UNITE GENET MOLEC MURINE,F-75724 PARIS 15,FRANCE

[2] HOP ENFANTS LA TIMONE,CTR GENET MED,INSERM,U242,F-13385 MARSEILLE 5,FRANCE

来源：

GENOMICS | 1993年 / 18卷 / 03期

关键词：

D O I：

10.1016/S0888-7543(11)80008-X

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A panel of 91 somatic cell hybrids containing deleted mouse X chromosomes and falling into seven nested intervals has been isolated and characterized from fusions involving the murine embryonic stem cell HD3. Many of the X chromosome breakpoints present in these hybrids fall within regions in which few or no other hybrids were previously available. The apparent enrichment for breakpoints lying within the Hprt-DXHX254E region is discussed in relation to both the nature of the embryonic stem cell fusions and the presence of the Fmr 1 gene associated with FRAXA in man within this span. © 1993, All rights reserved.

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页码：520 / 526

页数：7

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