TUMOR SURVEILLANCE - HOW TUMORS MAY RESIST MACROPHAGE-MEDIATED HOST DEFENSE

被引：51

作者：

RHODES, J ^{[1
]}

BISHOP, M ^{[1
]}

BENFIELD, J ^{[1
]}

机构：

[1] ADDENBROOKES HOSP,DEPT SURG,CAMBRIDGE CB2 2QQ,ENGLAND

来源：

SCIENCE | 1979年 / 203卷 / 4376期

关键词：

D O I：

10.1126/science.758686

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Both normal human serum and supernatant from explanted malignant tumors contained a heat-stable low-molecular-weight factor that inhibited monocyte activation in vitro. In contrast, serum from individuals with solid tumors enhanced monocyte activation. It is suggested that the systemic activation of monocytes that occurs in malignant disease may be an appropriate host response but that successful tumors may continue to grow because they subvert the normal physiological signal for inhibition of macrophage activation. Copyright © 1979 AAAS.

引用

页码：179 / 182

页数：4

共 42 条

[31] MONOCYTES AND MACROPHAGES IN MALIGNANT-MELANOMA .2. LYSIS OF ANTIBODY-COATED HUMAN ERYTHROCYTES AS AN ASSAY OF MONOCYTE FUNCTION [J].