CHANGES IN BLOOD-COAGULATION, PLATELET-FUNCTION, AND PLASMINOGEN-PLASMIN SYSTEM IN DIABETES

被引：71

作者：

KWAAN, HC ^{[1
]}

机构：

[1] VET AFFAIRS LAKESIDE MED CTR, DIV HEMATOL ONCOL, CHICAGO, IL USA

来源：

DIABETES | 1992年 / 41卷

关键词：

D O I：

10.2337/diab.41.2.S32

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The increased risk of thromboembolism in people with diabetes mellitus is in part due to changes in the hemostatic mechanism including abnormal platelet function leading to platelet activation, increase in several coagulation factors, decrease in natural anticoagulants, and impaired fibrinolytic activity. Both microangiopathy and atherosclerosis in people with diabetes will enhance the thrombotic potential of these abnormal hemostatic changes. The recent recognition of a role of the components of the plasminogen-plasmin system in many biologic functions at the cellular level has led to studies showing that the angiopathic complications of diabetes may also be caused by impaired plasminogen activator function.

引用

页码：32 / 35

页数：4

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