DETECTION OF BORRELIA-BURGDORFERI ANTIGENS IN CEREBROSPINAL-FLUID

被引:42
作者
COYLE, PK
DENG, Z
SCHUTZER, SE
BELMAN, AL
BENACH, J
KRUPP, LB
LUFT, B
机构
[1] UNIV MED & DENT NEW JERSEY, DEPT MED, NEWARK, NJ 07103 USA
[2] SUNY, HLTH SCI CTR, DEPT PATHOL, STONY BROOK, NY 11794 USA
[3] SUNY, HLTH SCI CTR, DEPT MED, STONY BROOK, NY 11794 USA
关键词
D O I
10.1212/WNL.43.6.1093
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
We examined CSF for Borrelia burgdorferi antigens using antigen-capture ELISA and Western (immuno) blot. Antigen-capture ELISA was positive in 38 of 77 (49%) CSF samples obtained from neurologic patients with presumed B burgdorferi infection, compared with one of 34 (3%) CSF samples obtained from other neurologic disease controls who came from a region endemic for Lyme disease. Western immunoblot was positive for B burgdorferi antigens in 12 of 22 (55%) CSF samples from the B burgdorferi infected groups, compared with none of 11 CSF samples from the control group. CSF antigen detection should prove helpful in evaluating patients for suspected neurologic Lyme disease.
引用
收藏
页码:1093 / 1097
页数:5
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