PREPARATION OF ENANTIOMERICALLY ENRICHED BROMOHYDRINS BY REACTION OF SULFOXIMINOOXIRANES WITH MGBR2 IN THE PRESENCE OF TETRA-BUTYLAMMONIUM BOROHYDRIDE

被引：5

作者：

BAILEY, PL

BRIGGS, AD

JACKSON, RFW

PIETRUSZKA, J

机构：

[1] UNIV NEWCASTLE UPON TYNE,DEPT CHEM,BEDSON BLDG,NEWCASTLE TYNE NE1 7RU,TYNE & WEAR,ENGLAND

[2] UNIV HAMBURG,INST ORGAN CHEM,W-2000 HAMBURG 13,GERMANY

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 41期

关键词：

D O I：

10.1016/0040-4039(93)88118-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Treatment of enantiomerically pure N-tosylsulfoximinooxiranes 6 with MgBr2 in the presence of tetra-butylammonium borohydride gives enantiomerically enriched bromohydrins 3, together with small amounts of the simple primary alcohols. The bromohydrins are isolated in good yields with enantiomeric excess in the range 70% to 91% (as assessed by enantioselective g.l.c.).

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页码：6611 / 6614

页数：4

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