PRIMING OF ASSOCIATIVE LONG-TERM DEPRESSION IN THE DENTATE GYRUS BY THETA FREQUENCY SYNAPTIC ACTIVITY

被引：164

作者：

CHRISTIE, BR ^{[1
]}

ABRAHAM, WC ^{[1
]}

机构：

[1] UNIV OTAGO,NEUROSCI RES CTR,DUNEDIN,NEW ZEALAND

来源：

NEURON | 1992年 / 9卷 / 01期

基金：

加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1016/0896-6273(92)90222-Y

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Associative long-term synaptic depression (LTD) was investigated utilizing negatively correlated activity patterns in the medial and lateral perforant path inputs to the dentate gyrus in anesthetized rats. Normally only nonassociative, or heterosynaptic, LTD is elicited in naive pathways. We report here, however, that associative LTD in the lateral path is readily induced after being "primed" by a brief period of lateral path synaptic activity at a theta-rhythm frequency (5 Hz). Priming of associative LTD lasts at least 2 hr and is not seen following priming activity at non-theta frequencies (1 and 15 Hz). N-methyl-D-aspartate receptor activation is critical for establishing the priming effect, but not for the subsequent induction of the associative LTD. These data suggest that theta-rhythm activity in the dentate gyrus may predispose the system to a specific form of synaptic plasticity, associative LTD.

引用

页码：79 / 84

页数：6

共 30 条

[11] COMMISSURAL SYNAPSES, BUT NOT MOSSY FIBER SYNAPSES, IN HIPPOCAMPAL FIELD CA3 EXHIBIT ASSOCIATIVE LONG-TERM POTENTIATION AND DEPRESSION [J].