CONTROL OF GENE-EXPRESSION IN THE TEMPERATE COLIPHAGE-186 .10. THE CL REPRESSOR DIRECTLY REPRESSES TRANSCRIPTION OF THE LATE CONTROL GENE-B

被引:13
作者
DIBBENS, JA [1 ]
GREGORY, SL [1 ]
EGAN, JB [1 ]
机构
[1] UNIV ADELAIDE,DEPT BIOCHEM,ADELAIDE,SA 5000,AUSTRALIA
关键词
D O I
10.1111/j.1365-2958.1992.tb01441.x
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
We have found that the repressor of 186 lytic transcription, Cl, represses transcription of the late control gene B, with no involvement of the B protein itself. In clone studies we showed that Cl repressed transcription from the B promoter and that temperature inactivation of Clts led to B derepression. We conclude that CI repressor directly represses transcription of the B gene and, with prophage induction, it is probable that the inactivation of the CI repressor not only derepresses early lytic transcription, but also derepresses B gene transcription, leading to the activation of transcription from the late promoters.
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页码:2643 / 2650
页数:8
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