HOX GENE-EXPRESSION IN TELEOST FINS AND THE ORIGIN OF VERTEBRATE DIGITS

被引:287
作者
SORDINO, P [1 ]
VANDERHOEVEN, F [1 ]
DUBOULE, D [1 ]
机构
[1] UNIV GENEVA, DEPT ZOOL & ANIM BIOL, CH-1211 GENEVA 4, SWITZERLAND
关键词
D O I
10.1038/375678a0
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Hox genes are essential for growth and patterning of the tetrapod limb skeleton(1-5). Mice mutant for the Hoxd-13 gene have an important delay in morphogenesis owing to reduced proliferation(2). Based on the appearance of atavisms in such mice, we suggested that modifications of Hox gene regulation may have been a source of morphological variation during the evolution of tetrapod limbs(2,6). Pectoral and pelvic fins are homologous to fore- and hindlimbs, respectively. To compare the relative importance of Hox genes during fin versus limb morphogenesis, we cloned zebrafish (Danio rerio) HoxD and HoxA complex genes and analysed their expression during fin development. The results suggest a scheme for the fin-limb transition in which the distal autopods (digits) are neomorphic structures produced by unequal proliferation of the posterior part of an ancestral appendix.
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页码:678 / 681
页数:4
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