SYNTHESIS AND ANTI-HIV ACTIVITY OF 3'-DEOXY-3'-(N-HYDROXYAMINO) ANALOGS OF NUCLEOSIDES

被引：11

作者：

TRONCHET, JMJ

ZSELY, M

CAPEK, K

DENAIDE, FD

机构：

[1] Institute of Pharmaceutical Chemistry, University of Geneva, CH-1211 Geneva 4, Sciences II

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 12期

关键词：

D O I：

10.1016/S0960-894X(00)80464-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

3'-Deoxy analogues of thymidine and uridine bearing a 3'-N-alkyl-(or N-aralkyl) -N-hydroxyamino group either on the alpha or the beta face of the furanose ring have been prepared. One of these (13), exhibited a moderate anti-HIV activity.

引用

页码：1723 / 1728

页数：6

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