POSSIBLE MECHANISM OF 5-METHOXY-N,N-DIMETHYLTRYPTAMINE-INDUCED TURNING BEHAVIOR IN DRN LESIONED RATS

被引：8

作者：

BLACKBURN, TP ^{[1
]}

COX, B ^{[1
]}

HEAPY, CG ^{[1
]}

LEE, TF ^{[1
]}

机构：

[1] ICI LTD, DEPT ALLGEMEINE BOT, DEPT BIOSCI 2, MACCLESFIELD SK10 4TG, CHESHIRE, ENGLAND

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1982年 / 16卷 / 01期

关键词：

D O I：

10.1016/0091-3057(82)90004-1

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

5-Methoxy-N,N-dimethyltryptamine (5-MeODMT) (7.5 mg/kg s.c.) caused a contralateral turning in rats with a unilateral lesion of the dorsal raphe nucleus (DRN). This turning behavior was blocked by pretreatment with putative 5-HT (serotonin) antagonists, methysergide, cyproheptadine and cinanserin. The peripheral 5-HT antagonist, xylamidine, also prevented the response to 5-MeODMT. Of the other neurotransmitter antagonists, only haloperidol was active; hyoscine, picrotoxin, naloxone and strychnine were ineffective. Pretreatment with .alpha.-methyl-p-tyrosine (.alpha.-MT) also significantly reduced the turning response to 5-MeODMT. A central dopaminergic system is involved in 5-MeODMT-induced turning behavior. This suggestion is supported by the finding that an ipsilateral turning in response to 5-MeODMT was observed in the rats with additional 6-hydroxydopamine (6-OHDA) lesions of the medial forebrain bundle (MFB). The possible mechanisms by which 5-MeODMT induced turning in DRN lesioned rats are discussed.

引用

页码：7 / 11

页数：5

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