SHORT-TERM-MEMORY AND COGNITIVE VARIABILITY IN ADULT FRAGILE-X FEMALES

被引:13
作者
DEVONFLINDT, R
BYBEL, B
CHUDLEY, AE
LOPES, F
机构
[1] UNIV MANITOBA,DEPT PEDIAT & CHILD HLTH,WINNIPEG R3T 2N2,MANITOBA,CANADA
[2] UNIV MANITOBA,DEPT HUMAN GENET,WINNIPEG R3T 2N2,MANITOBA,CANADA
[3] UNIV MANITOBA,DEPT PSYCHIAT,WINNIPEG R3T 2N2,MANITOBA,CANADA
[4] UNIV MANITOBA,FAC MED,WINNIPEG R3T 2N2,MANITOBA,CANADA
[5] WINNIPEG CHILD GUIDANCE CLIN,WINNIPEG,MANITOBA,CANADA
来源
AMERICAN JOURNAL OF MEDICAL GENETICS | 1991年 / 38卷 / 2-3期
关键词
FRAGILE-X SYNDROME; MEMORY DEFICITS; COGNITIVE PROFILES; VISUOSPATIAL ABILITIES; INTELLIGENCE TESTING;
D O I
10.1002/ajmg.1320380269
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
We investigated the possibility that adult fragile X[fra(X)] heterozygotes have a distinct or specific cognitive profile, with a particular focus on visuospatial and/or memory deficits. With a sample of 13 adult fra(X) female carriers (2 fra(X) positive) and age-matched control women, we performed 2 tests: Wechsler Adult Intelligence Scale-Revised (WAIS-R) and the Revised Visual Retention Test (RVRT). An identifiable cognitive profile was not evident in the study group, but significant differences were evident in RVRT performance in number correct and number of errors when compared to controls and normative data. The combination of the WAIS-R and RVRT data suggests that the short-term memory component of the tasks may be of more significance than visuospatial performance in the deficits observed.
引用
收藏
页码:488 / 492
页数:5
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