A MAJOR ROLE FOR CALCIUM-DEPENDENT POTASSIUM CURRENT IN ACTION-POTENTIAL REPOLARIZATION IN ADRENAL CHROMAFFIN CELLS

被引：6

作者：

PANCRAZIO, JJ ^{[1
]}

JOHNSON, PA ^{[1
]}

LYNCH, C ^{[1
]}

机构：

[1] UNIV VIRGINIA,HLTH SCI CTR,DEPT BIOMED ENGN,CHARLOTTESVILLE,VA 22908

来源：

BRAIN RESEARCH | 1994年 / 668卷 / 1-2期

关键词：

ACTION POTENTIAL; CALCIUM-DEPENDENT POTASSIUM CURRENT; CHROMAFFIN; NEUROENDOCRINE; REPOLARIZATION; WHOLE-CELL VOLTAGE-CLAMP;

D O I：

10.1016/0006-8993(94)90531-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To determine the extent which Ca dependent K current (I-KCa) contributes during an action potential (AP), bovine chromaffin cells were voltage-clamped using a pre-recorded AP as the command voltage waveform. Based on (1) differential sensitivity of I-KCa and Ca-independent K current (I-K) to tetraethylammonium; (2) measurements of AP currents under conditions where Ca activation of I-KCa had been abolished; and (3) blockade by charybdotoxin, I-KCa comprised 70-90% of the outward K current during AP repolarization. In addition, observations are made concerning the form of AP-evoked Ca current.

引用

页码：246 / 251

页数：6

共 24 条

[11] PROPERTIES OF 2 CALCIUM-ACTIVATED HYPERPOLARIZATIONS IN RAT HIPPOCAMPAL-NEURONS [J].

LANCASTER, B ;

NICOLL, RA .

JOURNAL OF PHYSIOLOGY-LONDON, 1987, 389 :187-203

[12] VARIETIES OF CALCIUM-ACTIVATED POTASSIUM CHANNELS [J].

LATORRE, R ;

OBERHAUSER, A ;

LABARCA, P ;

ALVAREZ, O .

ANNUAL REVIEW OF PHYSIOLOGY, 1989, 51 :385-399

[13] POTASSIUM CHANNELS IN CULTURED BOVINE ADRENAL CHROMAFFIN CELLS [J].

MARTY, A ;

NEHER, E .

JOURNAL OF PHYSIOLOGY-LONDON, 1985, 367 (OCT) :117-141

[14] CA-DEPENDENT K-CHANNELS WITH LARGE UNITARY CONDUCTANCE IN CHROMAFFIN CELL-MEMBRANES [J].

MARTY, A .

NATURE, 1981, 291 (5815) :497-500

[15] CALCIUM-ACTIVATED POTASSIUM CHANNELS - REGULATION BY CALCIUM [J].

MCMANUS, OB .

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES, 1991, 23 (04) :537-560

[16] CHARYBDOTOXIN, A PROTEIN INHIBITOR OF SINGLE CA-2(+)-ACTIVATED K+ CHANNELS FROM MAMMALIAN SKELETAL-MUSCLE [J].

MILLER, C ;

MOCZYDLOWSKI, E ;

LATORRE, R ;

PHILLIPS, M .

NATURE, 1985, 313 (6000) :316-318

[17]

PANCRAZIO JJ, 1993, MOL PHARMACOL, V43, P783

[18] 2 DISTINCT CA-DEPENDENT K-CURRENTS IN BULLFROG SYMPATHETIC-GANGLION CELLS [J].

PENNEFATHER, P ;

LANCASTER, B ;

ADAMS, PR ;

NICOLL, RA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (09) :3040-3044

[19] ACTION-POTENTIAL REPOLARIZATION AND A FAST AFTER-HYPERPOLARIZATION IN RAT HIPPOCAMPAL PYRAMIDAL CELLS [J].

STORM, JF .

JOURNAL OF PHYSIOLOGY-LONDON, 1987, 385 :733-759

[20] MULTIPLE POTASSIUM CONDUCTANCES AND THEIR ROLE IN ACTION-POTENTIAL REPOLARIZATION AND REPETITIVE FIRING BEHAVIOR OF NEONATAL RAT HYPOGLOSSAL MOTONEURONS [J].

VIANA, F ;

BAYLISS, DA ;

BERGER, AJ .

JOURNAL OF NEUROPHYSIOLOGY, 1993, 69 (06) :2150-2163

← 1 2 3 →