2 CLASSES OF SPONTANEOUS GABA-MEDIATED MINIATURE SYNAPTIC CURRENTS IN CULTURED RAT HIPPOCAMPAL-NEURONS

被引：16

作者：

VAUTRIN, J

SCHAFFNER, AE

BARKER, JL

机构：

[1] NINCDS,NEUROPHYSIOL LAB,BLDG 36,ROOM 2C02,BETHESDA,MD 20892

[2] UNIV PARIS 12,PHYSIOL GEN LAB,F-94010 CRETEIL,FRANCE

来源：

NEUROSCIENCE LETTERS | 1992年 / 138卷 / 01期

关键词：

QUANTUM; GABA; HIPPOCAMPAL NEURON; TRANSMITTER RELEASE; DISSOCIATED CELL CULTURE; CL-; CONDUCTANCE;

D O I：

10.1016/0304-3940(92)90474-L

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Amplitude and time course of spontaneous gamma-aminobutyric acid (GABA)-mediated miniature postsynaptic currents (MPSCs), recorded in cultured embryonic hippocampal neurons in presence of either tetrodotoxin (TTX) or increased external [Mg2+/Ca2+] ratio, revealed that they form two classes. The distribution of the most commonly recorded MPSCs was skewed both in terms of peak amplitude and rise-time(skew-MPSCs,mode:70 120pS). Another, less frequent class (mode: 1-3 nS) formed bell-shaped (bell-MPSCs) amplitude and rise-time distributions. MPSC initial slope did not correlate with rise time, indicating that smaller MPSCs were not electrotonically attenuated. Bell-MPSCs did not result from the integration of skew-MPSCs and both classes appeared to be composed of subunits.

引用

页码：67 / 71

页数：5

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