2 CLASSES OF SPONTANEOUS GABA-MEDIATED MINIATURE SYNAPTIC CURRENTS IN CULTURED RAT HIPPOCAMPAL-NEURONS

被引:16
作者
VAUTRIN, J
SCHAFFNER, AE
BARKER, JL
机构
[1] NINCDS,NEUROPHYSIOL LAB,BLDG 36,ROOM 2C02,BETHESDA,MD 20892
[2] UNIV PARIS 12,PHYSIOL GEN LAB,F-94010 CRETEIL,FRANCE
关键词
QUANTUM; GABA; HIPPOCAMPAL NEURON; TRANSMITTER RELEASE; DISSOCIATED CELL CULTURE; CL-; CONDUCTANCE;
D O I
10.1016/0304-3940(92)90474-L
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Amplitude and time course of spontaneous gamma-aminobutyric acid (GABA)-mediated miniature postsynaptic currents (MPSCs), recorded in cultured embryonic hippocampal neurons in presence of either tetrodotoxin (TTX) or increased external [Mg2+/Ca2+] ratio, revealed that they form two classes. The distribution of the most commonly recorded MPSCs was skewed both in terms of peak amplitude and rise-time(skew-MPSCs,mode:70 120pS). Another, less frequent class (mode: 1-3 nS) formed bell-shaped (bell-MPSCs) amplitude and rise-time distributions. MPSC initial slope did not correlate with rise time, indicating that smaller MPSCs were not electrotonically attenuated. Bell-MPSCs did not result from the integration of skew-MPSCs and both classes appeared to be composed of subunits.
引用
收藏
页码:67 / 71
页数:5
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