INCREASE IN SEROTONIN LEVELS IN THE DOG ILEUM AND BLOOD BY CISPLATIN AS MEASURED BY MICRODIALYSIS

被引：51

作者：

FUKUI, H ^{[1
]}

YAMAMOTO, M ^{[1
]}

ANDO, T ^{[1
]}

SASAKI, S ^{[1
]}

SATO, S ^{[1
]}

机构：

[1] TAKEDA CHEM IND LTD,DIV PHARMACEUT DEV,DRUG SAFETY RES LABS,6-10-1 HIMURO CHO,TAKATSUKI,OSAKA 569,JAPAN

来源：

NEUROPHARMACOLOGY | 1993年 / 32卷 / 10期

关键词：

CISPLATIN; DOG; MICRODIALYSIS; 5-HT; ENTEROCHROMAFFIN CELLS; VOMITING;

D O I：

10.1016/0028-3908(93)90060-G

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Involvement of ileal and circulating serotonin (5-HT) levels in cisplatin-induced emesis was examined using a microdialysis technique and an extraction method in dogs. The 5-HT levels in the ileal dialysate were increased to 232-294% of the basal level from 100 to 180 min after cisplatin administration (3 mg/kg, i.v.) and had returned to the basal level 280 min after dosing. The 5-HT levels in the blood dialysate were increased to 424-2165% from 140 to 180 min after dosing. The concentrations of 5-HT determined by HPLC following extraction were increased to 271% in the ileal mucosa and to 478% in plasma 3 hr after dosing. In immunohistochemistry, the number of 5-HT-immunoreactive cells was increased to 166% in the ileal mucosa following cisplatin treatment. These results strongly suggest that increases in the release and synthesis of 5-HT in the gut, probably in the enterochromaffin cells, are intimately involved in cisplatin-induced emesis.

引用

页码：959 / 968

页数：10

共 48 条

[11] 5-HYDROXYTRYPTAMINE M-RECEPTOR ANTAGONISM TO PREVENT CISPLATIN-INDUCED EMESIS [J].