LOW-TEMPERATURE HEAT-DEPROTEINATED COMPACT-BONE TO HEAL LARGE BONE DEFECTS

被引:25
作者
GUIZZARDI, S [1 ]
RASPANTI, M [1 ]
MARTINI, D [1 ]
SCANDROGLIO, R [1 ]
GOVONI, P [1 ]
RUGGERI, A [1 ]
机构
[1] UNIV BOLOGNA, INST HUMAN ANAT, I-40126 BOLOGNA, ITALY
关键词
BIOMATERIALS; CALCINED BONE; OSTEOCONDUCTION; BONE REPAIR;
D O I
10.1016/0142-9612(95)93118-W
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
The potential of low-temperature (400 degrees C), heat-treated bone matrix in osteorepair has been evaluated in vivo by implantation into defects artificially created in rodent tibia. Histological and ultrastructural analysis of the bone-implant interface has been carried out on samples obtained at 1 to 6 weeks operation. The obtained data showed that calcined bone is well tolerated and does not cause acute chronic inflammatory reactions. Osteoid tissue, tightly adhered to the implant, appears within 2 we of the operation, while after 6 weeks newly formed bone surrounds and infiltrates the implant. Of greater note, the detection of good adhesion between bone and implant ultrastructurally is demonstrated by the absence of fibrillar connective tissue at the interface. For these reasons, our preliminary observations suggest that low-temperature calcined bone (biological apatite or heat-deproteinated bone) may have a rightful place among the osteointegrators.
引用
收藏
页码:931 / 936
页数:6
相关论文
共 42 条
[21]   INTERACTION OF BIODEGRADABLE BETA-WHITLOCKITE CERAMICS WITH BONE TISSUE - AN INVIVO STUDY [J].
KLEIN, CPAT ;
DEGROOT, K ;
DRIESSEN, AA ;
VANDERLUBBE, HBM .
BIOMATERIALS, 1985, 6 (03) :189-192
[22]  
KLEIN CPAT, 1986, BIOMATERIALS, V7, P144
[23]   TISSUE-REACTIONS TO CALCINED BONE-GRAFT [J].
KUROSAWA, H ;
AOKI, H ;
AKAO, M .
BIOMATERIALS, 1986, 7 (02) :132-136
[24]  
LEMONS JE, 1990, CLIN ORTHOP RELAT R, V261, P153
[25]   THE ROLE OF HYDRATED SILICA, TITANIA, AND ALUMINA IN INDUCING APATITE ON IMPLANTS [J].
LI, PJ ;
OHTSUKI, C ;
KOKUBO, T ;
NAKANISHI, K ;
SOGA, N ;
DEGROOT, K .
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 1994, 28 (01) :7-15
[26]   DIFFERENCES IN CERAMIC BONE INTERFACE BETWEEN SURFACE-ACTIVE CERAMICS AND RESORBABLE CERAMICS - A STUDY BY SCANNING AND TRANSMISSION ELECTRON-MICROSCOPY [J].
NEO, M ;
KOTANI, S ;
FUJITA, Y ;
NAKAMURA, T ;
YAMAMURO, T ;
BANDO, Y ;
OHTSUKI, C ;
KOKUBO, T .
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 1992, 26 (02) :255-267
[27]   THE MATERIAL SCIENCE OF CALCIUM-PHOSPHATE CERAMICS [J].
OSBORN, JF ;
NEWESELY, H .
BIOMATERIALS, 1980, 1 (02) :108-111
[28]  
PAJAMAKI KJJ, 1993, ANN CHIR GYNAECOL FE, V82, P137
[29]  
Peelen J, 1977, SCI CERAM, V9, P226
[30]  
Piattelli A, 1993, Int J Oral Maxillofac Implants, V8, P309