ACCUMULATION OF TUBULAR STRUCTURES IN OLIGODENDROGLIAL AND NEURONAL CELLS AS THE BASIC ALTERATION IN MULTIPLE SYSTEM ATROPHY

被引:180
作者
PAPP, MI [1 ]
LANTOS, PL [1 ]
机构
[1] INST PSYCHIAT, DEPT NEUROPATHOL, LONDON SE5 8AF, ENGLAND
关键词
GLIAL; NEURONAL CYTOPLASMIC INCLUSION; NUCLEAR INCLUSION; TUBULAR STRUCTURE; CIRCULAR PROFILE;
D O I
10.1016/0022-510X(92)90286-T
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
In 8 brains of patients with various combinations of striatonigral degeneration, olivopontocerebellar atrophy and Shy-Drager syndrome, inclusion bodies were demonstrated in the cytoplasm and nucleus of both neuronal and oligodendroglial cells and in neuronal processes by means of silver staining, immunocytochemistry and electron microscopy. Differing from oligodendroglial cytoplasmic inclusions recognized by anti-ubiquitin, anti-alpha- and anti-beta-tubulin, and anti-tau antibodies, neuronal cytoplasmic inclusions were stained only by anti-ubiquitin antibody but not with those raised against cytoskeletal proteins. Tubular structures forming the inclusion bodies irrespective of their glial or neuronal location, have fuzzy cover and side extensions which make them similar to the linear structures described in motor neuron diseases. Our study proves that the accumulation of abnormal tubular structures in both oligodendrocytes and neurons is the basic pathological alteration in multiple system atrophy and defines multiple system atrophy as a group of diseases with similar cellular pathology or as a nosological entity.
引用
收藏
页码:172 / 182
页数:11
相关论文
共 32 条
[11]   CYTOPLASMIC ARGYROPHILIC INCLUSIONS IN NEURONS OF PONTINE NUCLEI IN PATIENTS WITH OLIVOPONTOCEREBELLAR ATROPHY - IMMUNOHISTOCHEMICAL AND ULTRASTRUCTURAL STUDIES [J].
KATO, S ;
NAKAMURA, H .
ACTA NEUROPATHOLOGICA, 1990, 79 (06) :584-594
[12]   LEWY BODY-LIKE HYALINE INCLUSIONS IN SPORADIC MOTOR NEURON DISEASE ARE UBIQUITINATED [J].
KATO, T ;
KATAGIRI, T ;
HIRANO, A ;
KAWANAMI, T ;
SASAKI, H .
ACTA NEUROPATHOLOGICA, 1989, 77 (04) :391-396
[13]   ULTRASTRUCTURAL-STUDY OF CHROMATOLYTIC NEURONS IN AN ADULT-ONSET SPORADIC CASE OF AMYOTROPHIC LATERAL SCLEROSIS [J].
KUSAKA, H ;
IMAI, T ;
HASHIMOTO, S ;
YAMAMOTO, T ;
MAYA, K ;
YAMASAKI, M .
ACTA NEUROPATHOLOGICA, 1988, 75 (05) :523-528
[14]   CYTOSKELETAL ABNORMALITIES IN MOTOR NEURON DISEASE - AN IMMUNOCYTOCHEMICAL STUDY [J].
LEIGH, PN ;
DODSON, A ;
SWASH, M ;
BRION, JP ;
ANDERTON, BH .
BRAIN, 1989, 112 :521-535
[15]   UBIQUITIN DEPOSITS IN ANTERIOR HORN CELLS IN MOTOR NEURON DISEASE [J].
LEIGH, PN ;
ANDERTON, BH ;
DODSON, A ;
GALLO, JM ;
SWASH, M ;
POWER, DM .
NEUROSCIENCE LETTERS, 1988, 93 (2-3) :197-203
[16]   SUBSTRUCTURE OF 20 NM FILAMENTS OF PROGRESSIVE SUPRANUCLEAR PALSY [J].
MONTPETIT, V ;
CLAPIN, DF ;
GUBERMAN, A .
ACTA NEUROPATHOLOGICA, 1985, 68 (04) :311-318
[17]   CLASSIC AND GENERALIZED VARIANTS OF PICKS DISEASE - A CLINICOPATHOLOGICAL, ULTRASTRUCTURAL, AND IMMUNOCYTOCHEMICAL COMPARATIVE-STUDY [J].
MUNOZGARCIA, D ;
LUDWIN, SK .
ANNALS OF NEUROLOGY, 1984, 16 (04) :467-480
[18]   IMMUNOCYTOCHEMICAL AND ULTRASTRUCTURAL STUDIES OF LOWER MOTOR NEURONS IN AMYOTROPHIC LATERAL SCLEROSIS [J].
MURAYAMA, S ;
MORI, H ;
IHARA, Y ;
BOULDIN, TW ;
SUZUKI, K ;
TOMONAGA, M .
ANNALS OF NEUROLOGY, 1990, 27 (02) :137-148
[19]   IMMUNOCYTOCHEMICAL AND ULTRASTRUCTURAL STUDIES OF PICKS DISEASE [J].
MURAYAMA, S ;
MORI, H ;
IHARA, Y ;
TOMONAGA, M .
ANNALS OF NEUROLOGY, 1990, 27 (04) :394-405
[20]   IMMUNOCYTOCHEMICAL AND ULTRASTRUCTURAL-STUDY OF LEWY BODY-LIKE HYALINE INCLUSIONS IN FAMILIAL AMYOTROPHIC LATERAL SCLEROSIS [J].
MURAYAMA, S ;
OOKAWA, Y ;
MORI, H ;
NAKANO, I ;
IHARA, Y ;
KUZUHARA, S ;
TOMONAGA, M .
ACTA NEUROPATHOLOGICA, 1989, 78 (02) :143-152