GLUCOCORTICOID HORMONES REDUCE THE EXPRESSION OF MAJOR HISTOCOMPATIBILITY CLASS-I ANTIGENS ON HUMAN EPITHELIAL-CELLS

被引：29

作者：

DOEBERITZ, MV ^{[1
]}

KOCH, S ^{[1
]}

DRZONEK, H ^{[1
]}

HAUSEN, HZ ^{[1
]}

机构：

[1] GERMAN CANC RES CTR, INST IMMUNOL, W-6900 HEIDELBERG 1, GERMANY

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 1990年 / 20卷 / 01期

关键词：

D O I：

10.1002/eji.1830200106

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Expression of a critical level of major histocompatibility complex (MHC) class I antigens on epithelial cells is a prerequisite for the action of specific cytolytic immune response cells. Glucocorticoid hormones have strong immunosuppressive effects. Therefore, we investigated the influence of the synthetic glucocorticoid dexamethasone on the expression level of MHC class I antigens on human epithelial cell lines. Long‐term treatment with dexamethasone leads to reduced MHC class I surface antigen expression and to decreased total membrane‐bound MHC class I protein. The steady‐state mRNA level is significantly decreased and the transcription rate of MHC class I genes is reduced. Copyright © 1990 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim

引用

页码：35 / 40

页数：6

共 60 条

[41] ENHANCEMENT OF EXPRESSION OF HISTOCOMPATIBILITY ANTIGENS OF MOUSE LYMPHOID-CELLS BY INTERFERON INVITRO
LINDAHL, P
LEARY, P
GRESSER, I
[J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1974, 4 (12) : 779 - 784
[42] ENHANCED TRANSCRIPTION OF C-MYC IN BURSAL LYMPHOMA-CELLS REQUIRES CONTINUOUS PROTEIN-SYNTHESIS
LINIAL, M
GUNDERSON, N
GROUDINE, M
[J]. SCIENCE, 1985, 230 (4730) : 1126 - 1132
[43] MCMILLAN VM, 1988, J IMMUNOL, V140, P2549
[44] MELTON DA, 1984, NUCLEIC ACIDS RES, V12, P7035, DOI 10.1093/nar/12.18.7035
[45] MURINE LEUKEMIA-VIRUS SEQUENCES ARE ENCODED IN THE MURINE MAJOR HISTOCOMPATIBILITY COMPLEX
MERUELO, D
KORNREICH, R
ROSSOMANDO, A
PAMPENO, C
MELLOR, AL
WEISS, EH
FLAVELL, RA
PELLICER, A
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (06): : 1804 - 1808
[46] NEGATIVE REGULATION OF THE MAJOR HISTOCOMPATIBILITY CLASS-I GENE IN UNDIFFERENTIATED EMBRYONAL CARCINOMA-CELLS
MIYAZAKI, J
APPELLA, E
OZATO, K
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (24) : 9537 - 9541
[47] EPITHELIUM-SPECIFIC SURFACE GLYCOPROTEIN OF MR 34,000 IS A WIDELY DISTRIBUTED HUMAN CARCINOMA MARKER
MOLDENHAUER, G
MOMBURG, F
MOLLER, P
SCHWARTZ, R
HAMMERLING, GJ
[J]. BRITISH JOURNAL OF CANCER, 1987, 56 (06) : 714 - 721
[48] GLUCOCORTICOIDS CONTROL PHOSPHOENOLPYRUVATE CARBOXYKINASE GENE-EXPRESSION IN A TISSUE SPECIFIC MANNER
NECHUSHTAN, H
BENVENISTY, N
BRANDEIS, R
RESHEF, L
[J]. NUCLEIC ACIDS RESEARCH, 1987, 15 (16) : 6405 - 6417
[49] NIEDERWIESER D, 1988, J IMMUNOL, V140, P2556
[50] INHIBITORY EFFECTS OF HYDROCORTISONE UPON PHYTOHEMAGGLUTININ-INDUCED RNA-SYNTHESIS IN HUMAN LYMPHOCYTES
ONO, T
TERAYAMA, H
TAKAKU, F
NAKAO, K
[J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1968, 161 (02) : 361 - &

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