SYNTHESIS AND CELL-ADHESION PROPERTIES OF CYCLO(-ARG-GLY-ASP-SER-LYS-), A CONSTRAINED ANALOG OF THE ACTIVE DOMAIN OF FIBRONECTIN

被引：6

作者：

DAVIES, JS ^{[1
]}

ENJALBAL, C ^{[1
]}

WISE, CJ ^{[1
]}

WEBB, SE ^{[1
]}

JONES, GE ^{[1
]}

机构：

[1] UNIV LONDON KINGS COLL,RANDALL INST,LONDON WC2B 5RL,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1994年 / 14期

关键词：

D O I：

10.1039/p19940002011

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Details of the synthesis of the protected pentapeptide linear precursor on a resin with an acid-labile linker, and its subsequent cyclisation to cyclo(-Arg-Gly-Asp-Ser-Lys-) are presented. The cyclopentapeptide, which is known to exist in solution in a beta- and gamma-turn conformation, shows specific differences in its effect on adhesion and cell spreading for fibroblast 3T3 and macrophage Bac 1 cells.

引用

页码：2011 / 2015

页数：5

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